The adopted son of the city of Chennai, MS Dhoni, has scored most ODI runs at the MA Chidambaram Stadium. The former Indian wicketkeeper batsman has scored 401 runs in six innings at an incredible average of 100.25 and a strike rate of 101.77. Dhoni once played a terrific knock here, scoring 139* against Africa XI while playing for Asia XI. Just like the other Indian cricket grounds, Virat Kohli has a great ODI record here too. He is second on the list of leading run-getters here with 283 runs in seven innings at an average of 40.42 and a strikeout rate of 87.88. Virat scored a classy 138 against South Africa here. Yuvraj Singh has scored 257 runs in seven innings at an average of 64.25 and a strike rate of 92.11 here. He is third on the list. Yuvraj scored a fighting 113 here in the 2011 World Cup against the West Indies. Below is the list of leading runners at this venue.
| Player | Span | Matches | Innings | Not Out | Runs | Highest Score | Average | Strike Rate | 100 | 50 |
| MS Dhoni (India) | 2007-2017 | 6 | 6 | 2 | 401 | 139* | 100.25 | 101.77 | 2 | 1 |
| Virat Kohli (India) | 2010-2019 | 7 | 7 | 0 | 283 | 138 | 40.42 | 87.88 | 1 | 2 |
| Yuvraj Singh (India) | 2003-2012 | 7 | 7 | 3 | 257 | 113 | 64.25 | 92.11 | 1 | 0 |
| Geoff Marsh (Australia) | 1987-1989 | 3 | 3 | 0 | 246 | 110 | 82 | 66.3 | 1 | 2 |
| AB de Villiers (South Africa) | 2007-2015 | 4 | 4 | 0 | 220 | 112 | 55 | 98.21 | 1 | 1 |
| Saeed Anwar (Pakistan) | 1997-1997 | 1 | 1 | 0 | 194 | 194 | 194 | 132.87 | 1 | 0 |
| Sachin Tendulkar (India) | 1994-2011 | 6 | 6 | 1 | 190 | 68 | 38 | 77.23 | 0 | 2 |
| Steve Waugh (Australia) | 1987-1996 | 4 | 4 | 3 | 176 | 59* | 176 | 103.52 | 0 | 2 |
| Rahul Dravid (India) | 1997-2007 | 3 | 3 | 0 | 168 | 107 | 56 | 88.88 | 1 | 1 |
| Brian Lara (West Indies) | 1994-2007 | 2 | 2 | 0 | 157 | 83 | 78.5 | 91.81 | 0 | 2 |
